Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20 )

Product code: 10-1007

Clonality : Monoclonal
Application : WB
Reactivity : Human

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Shipping Info:

2000 throughout India Order now and get it on next 3-4 working days (Major Cities)

Gene : TNFAIP3
Gene ID : 7128
Uniprot ID : P21580
Alternative Name : TNFAIP3, OTUD7C
Format : Purified
Amount : 100 µg
Clone name : ABM1G20
Isotype : Mouse IgG1 Kappa
Immunogen Information : A partial length recombinant protein from C terminal portion of A20 was used as the immunogen for this antibody.

A20 (also known as TNFAIP3) is a potent anti-inflammatory signaling molecule that restricts multiple intracellular signaling cascades. It is a pleiotropically expressed cytoplasmic protein, the expression of which is regulated at both the transcriptional and the post-transcriptional level. In most cell types, A20 is rapidly induced by NF-KappaB in a negative feedback loop that maintains a transient NF-KappaB response.  In addition, post-translational modifications of A20 — including phosphorylation, protein cleavage, glycosylation and ubiquitylation — may serve to support or restrict its activity. A20 targets the E3 ubiquitin ligase TRAF6 in the TLR4/IL-1R pathway by antagonizing interactions with the E2 enzymes Ubc13 and UbcH5c. A20 also promotes cell-survival signals, adding another dimension to its ability to regulate dynamic immune responses. 

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 4-6 µg/ml


Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20 )

Product code: 10-1007
mg

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