Monoclonal Antibody to Caspase-3 (Clone: ABM11D3)

Product code: 10-1004

Clonality : Monoclonal
Application : IHC, FACS, WB
Reactivity : Human

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Shipping Info:

2000 (throughout India)

Order now and get it on next 3-4 working days* (Major Cities)


Gene : CASP3
Gene ID : 836
Uniprot ID : P42574
Alternative Name : Apopain, Cysteine protease CPP32, SREBP cleavage activity, SCA-1
Format : Purified
Amount : 100 µg
Clone name : ABM11D3
Isotype : Mouse IgG1
Immunogen Information : Full length recombinant protein of Caspase-3 was used as the immunogen for this antibody.

Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

WB: 0.5-1 µg/ml, FACS: 0.5-1 µg/10^6, IHC: 5-10 µg/ml


Monoclonal Antibody to Caspase-3 (Clone: ABM11D3)

Product code: 10-1004
mg

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