Polyclonal antibody to APAF-1

Product code: 20-1002

Clonality : Polyclonal
Application : IP, IHC, WB
Reactivity : Human

Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

50 µl

Bulk Order

Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : APAF1
Gene ID : 317
Uniprot ID : O14727
Alternative Name : APAF1, KIAA0413
Format : Sera
Amount : 50 µl
Isotype : Rabbit IgG
Immunogen Information : A synthetic peptide of APAF-1 protein (amino acids 264-282 GPKYVVPVESSLGKEKGLE) was used as the immunogen for this antibody

Apaf 1 (apoptosis protease-activating factor-1) is a key regulator of the mitochondrial apoptotic pathway, being the central element of the multimeric apoptosome.� The apoptosome consists of cytochrome c, procaspase-9 and seven Apaf 1 monomers, and is considered to�be core apoptotic machinery�that executes mitochondria-dependent apoptosis. Cytochrome c, normally compartmentalized in the mitochorndria, is released into the cytoplasm following apoptotic stimuli.�� Apaf 1 binds cytochrome c in the cytoplasm and in the presence of dATP/ATP forms the apoptosome.� The apoptosome binds procaspase-9 and promotes its autocatalytic activation.� Active caspase-9, in turn, activates downstream caspases including 3, 6, and 7 contributing to the proteolytic caspase activation cascade which leads to cell death. �

Content : 50 µl sera
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200

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