Polyclonal antibody to CD40/TNFRSF5

Product code: 20-1053

Clonality : Polyclonal
Application : WB, IHC, IP
Reactivity : Dog, Gerbil, Human, Mouse, Rat

Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Size
Price
50 µl
12,000.00 


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Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : CD40
Gene ID : 958
Uniprot ID : P25942
Alternative Name : CD40, TNFRSF5
Format : Sera
Amount : 50 µl
Isotype : Rabbit IgG
Immunogen Information : A recombinant protein containing the short cytoplasmic domain of the human CD40 molecule was used as immunogen for this antibody
CD40 and its ligand CD154 are members of the tumor necrosis factor receptor (TNFR) and TNF families, respectively, that play key roles in signaling pathways mediating cell growth, survival and differentiation in B-lymphocytes. The CD40 receptor is a 45-50 kDa glycoprotein and is expressed on the surface of B-lymphocytes, some activated T-cells, monocytes, follicular dendritic cells, basal epithelial cells, and in some epithelial and non-epithelial carcinomas.The functions of CD40 have been most extensively studied in B-cells. Several distinct structural motifs in the CD40 cytoplasmic domain regaulate various CD40 signaling pathways. A major CD40 signaling pathway activated from CD154 ligand binding is the canonical pathway to the transcription factor family NFkB, a family of genes mediating immune and inflammatory responses.Although CD40 has been extensively studied as a plasma membrane-associated growth factor membrane receptor. it has also been identified in the cytoplasm and nucleus of normal and neoplastic B-lymphoid cells. The presence of CD40 in the nucleus of activated normal B lymphocytes and neoplastic B-lymphoid cells suggests that CD40 may play a more complex role in regulating essential growth and survival pathways in B-lymphocytes than previously thought.
Content : 50 µl sera
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200


Polyclonal antibody to CD40/TNFRSF5

Product code: 20-1053
mg

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