|
|
| Gene : |
TRAF2 |
| Gene ID : |
7186 |
| Uniprot ID : |
Q12933 |
| Alternative Name : |
TRAF2, TRAP3 |
| Format : |
Sera |
| Amount : |
50 µl |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A synthetic peptide of human TRAF-2 (amino acids 87-106 SSSAFPDNAARREVESLPAV) was used as immunogen for this antibody |
This antibody recognizes TRAF2, which is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 501 amino acids. It Links TNFRs (TNF Receptors) to the SAPKs (Stress-Activated Protein Kinases) and p38s. TRAF2 can activate ASK1 (Apoptosis Signal-Regulating Kinase-1) in vivo and can interact in vivo with the amino- and carboxyl-terminal noncatalytic domains of the ASK1 polypeptide. Expression of the amino-terminal noncatalytic domain of ASK1 can inhibit TNF and TRAF2 activation of SAPK. TRAF2 is a potential mediator of CD40 signaling. In vitro, TRAF2 and TRAF3 bind to the CD40 Cytoplasmic Tail (CD40CT) with much higher affinity than TRAF5 and TRAF6 (TNF Receptor Associated Factor-6) and that TRAF2 and TRAF3 bind to different residues of the CD40CT. The TRAF2-binding site of the CD40CT is critical for NF-KappaB and SAPK activation, as well as the UP-regulation of the ICAM1 (Intercellular Adhesion Molecule-1).
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
