Monoclonal Antibody to CD56 (Clone: 123C3)

Product code: 10-7504

Clonality : Monoclonal
Application : IHC, FACS
Reactivity : Human

Shipping Info:

2000 throughout India Order now and get it on next 3-4 working days (Major Cities)

 
Size
Price

Available Pack Size(s)

15,000.00 


Bulk Order


Shipping Info:

2000 throughout India Order now and get it on next 3-4 working days (Major Cities)

Gene : NCAM1
Gene ID : 4684
Uniprot ID : P13591
Alternative Name : NCAM1, NCAM
Format : Purified
Amount : 100 µg
Clone name : 123C3
Isotype : Mouse IgG1 Kappa
Immunogen Information : The immunogen for this CD56 antibody was a membrane preparation of a small cell lung carcinoma.

CD56, a 175-220KDa glycoprotein, is a member of the Ig super family. It is expressed as three major isoforms and consists of five Ig-like domains and two Fibronectin-type III domains in the extracellular region. The 135kDa isoform is the basic molecule which is glycosylated or sialylated to produce the mature species. CD56 is widely expressed in nervous system, on NK cells and a specific set of Tcells. CD56+ NK cells and Tcells are unique in their ability to mediate cell-mediated cytotoxicity against certain tumor cell targets without MHC restriction. Other physiological functions of CD56 include mediating cell adhesion through homophilic and heterophilic interaction and activating intracellular signaling pathways resulting in neutrite extension and fasciculation, migration and synapses formation in brain. CD56 is also vital for neuronal development and plasticity in adult brain. It is used as a tumor marker in various cancers such as NK lymphomas and Merkel cell carcinoma. NCAM is expressed on most neuroectodermal derived lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma. It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma and also on natural killer cells.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Immunohistochemical analysis: 1:100-1:200; Flowcytometry analysis: 1-2 µg/10^6 cells


Monoclonal Antibody to CD56 (Clone: 123C3)

Product code: 10-7504
mg

Can't read the image? click here to refresh.