Monoclonal Antibody to Desmoglein 3 (Clone: ABM4A31)

Product code: 10-7539

Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Gene : DSG3
Gene ID : 1830
Uniprot ID : P32926
Alternative Name : DSG3, CDHF6
Format : Purified
Amount : 100 µg
Clone name : ABM4A31
Isotype : Mouse IgG2b Kappa
Immunogen Information : A partial length recombinant Desmoglein 3 protein (amino acids 328-526) was used as the immunogen for this antibody.
DSG3 (Desmoglein 3) is a calcium-binding transmembrane glycoprotein component of desmosomes, conferring strong cell-cell adhesion. Desmosomes are button-like points of intercellular contact that allow the attachment of cytoskeletal elements to the plasma membrane at sites of cell-cell adhesion. DSG3 is expressed in basal and immediate suprabasal layers of skin. To maintain cell-cell adhesion DSG3 interacts with other desmosomal proteins, such as plakoglobin. Plakoglobin is closely related to Beta-catenin, which is a well-known downstream effector molecule in the canonical Wnt signaling pathway.DSG3 also promotes cancer cell growth and invasion through a plakoglobin-mediated signaling pathway.
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Immunohistochemical analysis: 1 µg/ml


Monoclonal Antibody to Desmoglein 3 (Clone: ABM4A31)

Product code: 10-7539
mg

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