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|
Gene : |
GCSAM |
Gene ID : |
257144 |
Uniprot ID : |
Q8N6F7 |
Alternative Name : |
GCSAM, GAL, GCET2 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ABM43E6 |
Isotype : |
Mouse IgG1 Kappa |
Immunogen Information : |
A full length human HGAL protein was used as the immunogen for this antibody |
Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1). HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.
Immunohistochemical analysis: 5 µg/ml