Monoclonal Antibody to HGAL (Clone: ABM43E6)

Product code: 10-7544

Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Gene : GCSAM
Gene ID : 257144
Uniprot ID : Q8N6F7
Alternative Name : GCSAM, GAL, GCET2
Format : Purified
Amount : 100 µg
Clone name : ABM43E6
Isotype : Mouse IgG1 Kappa
Immunogen Information : A full length human HGAL protein was used as the immunogen for this antibody
Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1). HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Immunohistochemical analysis: 5 µg/ml


Monoclonal Antibody to HGAL (Clone: ABM43E6)

Product code: 10-7544
mg

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