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Gene : |
ICAM1 |
Gene ID : |
3383 |
Uniprot ID : |
P05362 |
Alternative Name : |
ICAM1 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ABM5B10 |
Isotype : |
Mouse IgG1 Kappa |
Immunogen Information : |
A partial length recombinant protein from N terminal portion of ICAM-1 was used as the immunogen for this antibody. |
ICAM-1 is a transmembrane glycoprotein with a variable degree of glycosylation and is a fundamental component in many immune-related processes. The major functions of ICAM-1 are T-cell activation and leukocyte-endothelial cell interaction via lymphocyte function-associated antigen-1 and macrophage-1 antigen targeting. ICAM-1 is also known to be involved in experimental models of uveitis. In addition to uveitis, proliferative vitreoretinopathy, diabetic retinopathy, and macular pucker are all associated with ICAM-1 expression. ICAM-1 is associated with an inflammatory response, with the encoded protein being expressed on the cell membrane of several cell types including endothelial cells, epithelial cells, and fibroblasts. It is the most important receptor of human rhinovirus infection. Genetic variants in ICAM-1 gene have been shown to regulate the expression level and have been widely studied for possible genetic association with a range of degenerative and inflammatory diseases.
Western blot analysis: 2-4 µg/ml