|
|
| Gene : |
Pdcd1 |
| Gene ID : |
18566 |
| Uniprot ID : |
Q02242 |
| Alternative Name : |
Programmed cell death protein 1, Protein PD-1, CD279 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM5F42 |
| Isotype : |
Rat IgG2b, kappa |
| Immunogen Information : |
partial length recombinant protein (a.a 07-211) of mPD-1 was used as the immunogen for this antibody. |
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
