|
|
| Gene : |
CKMT1A |
| Gene ID : |
1159 |
| Uniprot ID : |
P12532 |
| Alternative Name : |
Creatine kinase mitochondrial 1A, creatine kinase
mitochondrial 1 (ubiquitous), creatine kinase U-type mitochondrial, Acidic-type
mitochondrial creatine kinase, Ubiquitous mitochondrial creatine kinase, CKMT1,
U-MtCK, mia-CK, EC 2.7.3, EC 2.7.3.2. |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
PAT17A2AT |
| Isotype : |
Mouse
IgG2b heavy chain and k light chain. |
| Immunogen Information : |
Anti-human CKMT1A mAb,
clone PAT17A2AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human CKMT1A protein
40-417 amino acids purified from E.
coli. |
CKMT1A is in charge of the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. CKMT1A is a member of the creatine kinase isoenzyme family and exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase arises in two different oligomeric forms: dimers and octamers, unlike the exclusively dimeric cytosolic creatine kinase isoenzymes. Numerous malignant cancers with poor prognosis have displayed overexpression of ubiquitous mitochondrial creatine kinase which is linked to high energy turnover and inability to remove cancer cells through apoptosis.
The antibody has been tested by ELISA, Western blot
analysis to assure specificity and reactivity. Since application varies,
however, each investigation should be titrated by the reagent to obtain optimal
results. Recommended starting dilution is 1:1000.
