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Gene : |
ASAP2 |
Gene ID : |
8853 |
Uniprot ID : |
O43150 |
Alternative Name : |
ASAP2, DDEF2, KIAA0400 |
Format : |
Purified |
Amount : |
100 µg |
Isotype : |
Rabbit IgG |
Immunogen Information : |
A partial length recombinant ASAP2 protein (amino acids 500-760) was used as the immunogen for this antibody. |
ASAP2 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2) or Development and differentiation-enhancing factor 2 (DDEF2) or Paxillin-associated protein with ARF GAP activity 3 (PAG3) is a multidomain protein containing two ANK repeats, one Arf-GAP domain, one PH domain and one SH3 domain. ASAP2 has two isoforms: PAPalpha and PAPbeta (111 and 106 kDa respectively) and both the isoforms are generally located in Golgi plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). ASAP2 regulates ARF-mediated vesicle budding when vesicular transport. ASAP2 has high level of expression in brain, kidney, and heart.
Western blot analysis: 2-4 µg/ml