Monoclonal Antibody to MBD2/MBD3 (Clone: ABM14A8)

Product code: 10-7006

Clonality : Monoclonal
Application : IHC, FACS, WB
Reactivity : Human

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2000 throughout India Order now and get it on next 3-4 working days (Major Cities)

Gene : MBD3
Gene ID : 53615
Uniprot ID : O95983
Alternative Name : MBD3
Format : Purified
Amount : 100 µg
Clone name : ABM14A8
Isotype : Mouse IgG1 Kappa
Immunogen Information : A partial length recombinant MBD3 protein (amino acids 1-290) was used as the immunogen for this antibody.

MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. This protein binds around 1 kb downstream of the transcription start site of a subset of ? 400 CpG island promoters that are characterized by the presence of active histone marks, RNA polymerase II (Pol2) and low to medium gene expression levels and H3K36me3 deposition. Methylated MBD2 is involved in silencing methylated tumor suppressor genes as well as activation of pro-metastatic genes. MBD2 also plays a key role in regulating expression of a range of genes that are associated with optimal DC (Dendritic cells) activation and function.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml, FACS analysis: 0.5 µg/10^6 cells


Monoclonal Antibody to MBD2/MBD3 (Clone: ABM14A8)

Product code: 10-7006
mg

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