|
|
| Gene : |
PRPS1 |
| Gene ID : |
5631 |
| Uniprot ID : |
P60891 |
| Alternative Name : |
ARTS, CMTX5, PPRibP, PRSI, DFN2, Ribose-phosphate
pyrophosphokinase 1, DFNX1, Phosphoribosyl pyrophosphate synthase I, PRS-I,
PRPS1, KIAA0967. |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
PAT1E11AT |
| Isotype : |
Mouse IgG2a heavy chain and k light chain. |
| Immunogen Information : |
Anti-human PRPS1 mAb,
clone PAT1E11AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human PRPS1 protein 1-318
amino acids purified from E. coli. |
PRPS1 catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. PRPS1 catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is essential for purine metabolism and nucleotide biosynthesis. Defects in PRPS1 result in phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome.
The
antibody has been tested by ELISA, Western blot analysis to assure specificity
and reactivity. Since application varies, however, each investigation should be
titrated by the reagent to obtain optimal results. Recommended starting
dilution is 1:1000.
