|
|
Gene : |
XPA |
Gene ID : |
7507 |
Uniprot ID : |
P23025 |
Alternative Name : |
XP1, XPAC, DNA repair protein complementing XP-A cells. |
Format : |
Purified |
Amount : |
20 µg |
Clone name : |
PAT37C5AT |
Isotype : |
Mouse IgG3 heavy chain and k light chain. |
Immunogen Information : |
Anti-human XPA mAb,
clone PAT37C5AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human XPA protein 1-273
amino acids purified from E. coli. |
DNA repair protein complementing XP-A cells, (XPA), is a member of the XPA family. XPA protein takes a part in DNA excision repair. It Inductees repair by binding to damaged sites with different affinities depending on the photoproduct and the transcriptional state of the region. Defects in XPA is the reason of xeroderma pigmentosum complementation group A (XP-A), which is infrequent human autosomal recessive disease which characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight, also may cause to neurological abnormalities.
The antibody has been tested by ELISA, Western blot
analysis to assure specificity and reactivity. Since application varies,
however, each investigation should be titrated by the reagent to obtain optimal
results. Recommended starting dilution is 1:1000.