Monoclonal antibody to mCD19 (Clone: 1D3 )

Product code: 10-4006

Clonality : Monoclonal
Application : FACS
Reactivity : Mouse

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2000 throughout India Order now and get it on next 3-4 working days (Major Cities)

Gene : Cd19
Gene ID : 12478
Uniprot ID : P25918
Alternative Name : Cd19
Format : Purified
Amount : 100 µg
Clone name : 1D3
Isotype : Rat IgG2a Kappa
Immunogen Information : Recombinant mouse CD19-transfected cell line was used as an immunogen for this antibody.

CD19 is a B-cell�specific cell-surface molecule of the Ig superfamily expressed by early pre-B cells in humans and mice until plasma cell differentiation. It plays a crucial role in mature B cell development as best exemplified by the finding that CD19 deficient mice have severely reduced mature B cell compartments. CD19 is specifically expressed in normal and neoplastic lymphoid cells. Human CD19 and mouse CD19 are functionally equivalent in vivo. Too high CD19 expression might result into too strong BCR signaling in the bone marrow and therefore causing negative selection. Too low CD19 expression might result into too little BCR signaling and thereby preventing the B cells to enter the mature pool (absence of positive selection). CD19 functions as the dominant signaling component of a multimolecular complex on the surface of mature B cells, alongside complement receptor CD21, and the tetraspanin membrane protein CD81 (TAPA-1), as well as CD225. CD19 plays a critical role in maintaining the balance between humoral, antigen-induced response and tolerance induction.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

FACS Analysis: 0.5-1 µg/10^6 cells


Monoclonal antibody to mCD19 (Clone: 1D3 )

Product code: 10-4006
mg

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