|
|
| Gene : |
DDX58 |
| Gene ID : |
23586 |
| Uniprot ID : |
O95786 |
| Alternative Name : |
DDX58 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM4H29 |
| Isotype : |
Mouse IgG1 Kappa |
| Immunogen Information : |
A partial length recombinant human RIG-I protein (amino acids 1-220) was used as the immunogen for this antibody. |
RIG-I (retinoic-acid-inducible gene I), also known as DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) is a 925-residue cytoplasmic viral RNA receptor, critically involved in the activation of the innate immune response to RNA virus infection. It is a member of the RIG-I-like receptor (RLR) family and is an essential intracellular sensor for several 5?-triphosphorylated RNA viruses. RIG-I elicits its antiviral interferon (IFN) responses by recognizing viral double-stranded RNAs (dsRNAs). Structurally it comprises a helicase domain, a C-terminal domain, and N-terminal CARDs (caspase activation recruitment domains) involved in activating MAVS (mitochondrial antiviral signaling protein). Upon binding of 5?-triphosphorylated RNA, RIG-I undergoes conformational changes and post-translational modifications that allow multimerization and interaction with the mitochondrial antiviral signaling protein (MAVS).
Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 15 µg/ml, Flowcytometric analysis: 0.5-1µg/10^6 cells
