|
|
| Gene : |
IKBKG |
| Gene ID : |
8517 |
| Uniprot ID : |
Q9Y6K9 |
| Alternative Name : |
IKBKG, FIP3, NEMO |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM15D9 |
| Isotype : |
Mouse IgG1 Kappa |
| Immunogen Information : |
A full length recombinant Ikk Gamma protein was used as the immunogen for this antibody. |
IKK is a trimeric protein complex consisting of two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit, IKKgamma. IKKgamma (also termed NEMO or IKBKG) regulates the kinase activity of IKKalpha/beta. IKKgamma plays a critical role in DNA damaged-induced NF-kappaB signaling in a role independent of its function in the IKK complex. While the biological importance of IKKgamma PTMs (Post-Translational Modifications) has been reported under a variety of stimuli, the detection of PTMs has numerous technical limitations. These limitations include both the transient nature of these modifications, as well as low overall abundance of modified IKKgamma inside the cell.
Western blot analysis: 2-4 µg/ml, Flowcytometric analysis: 0.5-1 µg/10^6 Cells
