Polyclonal Antibody to Cbx5

Product code: 11-12012

Clonality : Polyclonal
Application : WB
Reactivity : Human

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Gene : CBX5
Gene ID : 23468
Uniprot ID : P45973
Alternative Name : CBX5, HP1A
Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Immunogen Information : Full length recombinant Cbx5 protein was used as the immunogen for this antibody.

Chromobox homolog 5 (Cbx5), lso known as HP1 is an evolutionarily conserved non-histone chromosomal protein involved in many biological progresses, such as heterochromatin formation, transcriptional regulation, DNA recombination and damage repair, RNA interference, kinetochore protein assembly, chromatin condensation and sister chromatid cohesion regulation. It binds lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin, and plays a crucial role in forming higher-order chromatin structures.Cbx5 has a conserved N-terminal chromo domain (CD), 3 a non-conserved hinge region, and a C-terminal chromo shadow domain. It localizes to centromeres in interphase through its CD domain, whereas mitotic centromeric localization depends on the CSD domain (CSD). Down regulation of Cbx5 has also been linked to the higher invasive potential of breast cancer cells.

Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 1-2 µg/ml


Polyclonal Antibody to Cbx5

Product code: 11-12012
mg

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