Monoclonal Antibody to c-MYC (Clone: 9E10)

Product code: 10-10013

Clonality : Monoclonal
Application : WB
Reactivity : Human

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Gene : MYC
Gene ID : 4609
Uniprot ID : P01106
Alternative Name : MYC, BHLHE39
Format : Purified
Amount : 100 µg
Clone name : 9 E 10
Isotype : Mouse IgG1 Kappa
Immunogen Information : A synthetic peptide corresponding to amino acids 408-432 (AEEQKLISEEDLLRKRREQLKHKLE) of human c-Myc was used as the immunogen for this antibody.

c-Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. The Myc protein activates transcription as part of a heteromeric complex with Max. Myc protein represses the expression of Ferritin-H, which sequesters intracellular iron, and stimulates the expression of IRP2 (Iron Regulatory Protein-2), which increases the intracellular iron pool. Myc induces transcription of the E2F1, E2F2 and E2F3 genes. Myc-induced S phase and apoptosis requires distinct E2F activities. The induction of specific E2F activities is an essential component in the Myc pathways that control cell proliferation and cell fate decisions.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 2-4 µg/ml


Monoclonal Antibody to c-MYC (Clone: 9E10)

Product code: 10-10013
mg

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