Monoclonal Antibody to TLR6 (Clone: ABM1B50)-FITC Conjugated

Product code: 10-3002-F

Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : FITC

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Gene : TLR6
Gene ID : 10333
Uniprot ID : Q9Y2C9
Alternative Name : TLR6
Format : Purified
Amount : 100 µg
Clone name : ABM1B50
Isotype : Mouse IgG1 Kappa
Immunogen Information : A partial length recombinant TLR6 protein (amino acids 280-512) was used as the immunogen for this antibody.

TLR6 (Toll-Like Receptors 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 forms heterodimers with TLR1 and TLR2, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 in co-operation with TLR6 trigger inflammatory responses via activation of NF-kappaB, which regulates the transcription of inflammatory molecules. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Upon silencing, TLR6 significantly inhibited the pro-inflammatory cytokine levels, reactive nitrogen species generation and inducible nitric oxide synthase expression.

Purification : Protein G Chromatography
Content : 0.2 mg/ml in Tris buffer containing 0.05% Azide
Storage condition : Store the antibody at 4°C, stable for 6 months.

 FACS analysis: 0.5-1 µg/10^6 cells

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