Monoclonal Antibody to ALK-1 (Clone: ABM43C4)

Product code: 10-7542

Clonality : Monoclonal
Application : IHC, WB
Reactivity : Human

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Gene : ACVRL1
Gene ID : 94
Uniprot ID : P37023
Alternative Name : ACVRL1, ACVRLK1, ALK1
Format : Purified
Amount : 100 µg
Clone name : ABM43C4
Isotype : Mouse IgG1 Kappa
Immunogen Information : A partial length recombinant ALK-1 protein (amino acids 310-503) was used as the immunogen for this antibody
ALK-1 or Activin receptor-like kinase-1 is a type I cell surface receptor for the TGF-beta (transforming growth factor-beta) super family of proteins. It is expressed predominantly in endothelial cells with moderate expression in smooth muscle cells, myofibroblast, hepatic stellate cells, chondrocytes, monocytes, myoblasts, macrophages and fibroblasts. ALK-1 plays a pivotal role in vascular remodelling and angiogenesis. More specifically its key function is in arterial/venous differentiation during embryonic vascular development. Mutations in ALK-1 gene (12q11-14) causes HHT2 (Hereditary Haemorrhagic Telangiectasia type 2), an autosomal dominant multisystem vascular dysplasia caused by a haploinsufficiency mechanism.
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 1 µg/ml


Monoclonal Antibody to ALK-1 (Clone: ABM43C4)

Product code: 10-7542
mg

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