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|
Gene : |
MS4A1 |
Gene ID : |
931 |
Uniprot ID : |
P11836 |
Alternative Name : |
B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD_antigen: CD20 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
B9E9 |
Isotype : |
Mouse IgG2a, Kappa |
Immunogen Information : |
Lymphoblastoid cell line Daudi was used as the immunogen for this antibody. |
CD20 is clinically validated as an immunotherapy target for B-cell lymphomas and autoimmune diseases. CD20 consists of large, intracellular, amino- and carboxyterminal portions connected by 4 membrane-spanning domains. Its high expression on malignant B cells and its reported lack of shedding from the surface make CD20 an ideal target for antibody-mediated killing. Anti-CD20 antibodies are believed to mediate the therapeutic effect by activation of complement-dependent cytotoxicity (CDC) and largely by antibody-dependent cellular cytotoxicity exerted by recruitment of innate immune effector cells expressing the Fcgamma receptor IIIa.
FACS: 0.5-1 µg/10^6 cells