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Gene : |
ANO1 |
Gene ID : |
55107 |
Uniprot ID : |
Q5XXA6 |
Alternative Name : |
ANO1, DOG1, ORAOV2, TAOS2, TMEM16A |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
SPM580 |
Isotype : |
Mouse IgG1, kappa |
Immunogen Information : |
Recombinant human DOG-1 protein |
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);