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|
| Gene : |
EPCAM |
| Gene ID : |
4072 |
| Uniprot ID : |
P16422 |
| Alternative Name : |
EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
PAN-EpCAM (Cocktail) |
| Isotype : |
Mouse IgG1 s, kappa |
| Immunogen Information : |
Recombinant human Ep-CAM protein (full-length and fragments) |
It is a cocktail of four highly specific monoclonal antibodies (EGP40/826, EGP40/837, EGP40/1110, EGP40/1120) that recognize extracellular as well as intracellular domains of the epithelial cellular adhesion molecule (Ep-CAM). It is a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or Ep-CAM. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been suggested as a discriminator between basal cell and baso-squamous carcinomas, and squamous cell carcinoma of the skin.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Western Blot (1-2ug/ml); ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),
