Monoclonal Antibody to mTLR9 (Clone: ABM4D70)

Product code: 10-3029

Clonality : Monoclonal
Application : FACS, WB
Reactivity : Mouse

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Gene : Tlr9
Gene ID : 81897
Uniprot ID : Q9EQU3
Alternative Name : Tlr9
Format : Purified
Amount : 100 µg
Clone name : ABM4D70
Isotype : Rat IgG2a Kappa
Immunogen Information : A partial length recombinant mTLR9 protein (amino acids 602-860) was used as the immunogen for this antibody.

Mouse Toll-like receptor 9 (mTLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. TLR9 is normally expressed in endosomes/lysosomes where it is activated by pathogen-derived DNA. It has modulatory effect on the mucosal immune system, influence susceptibility to allergic sensitization to foods (22718261). TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. TLR9 signaling plays an important role in the development of robust protective immunity, proper recruitment and function of effector cells (lymphocytes and macrophages), and, ultimately, effective cryptococcal clearance from the infected lungs (20581055). It is involved in the pathogenesis of cardiovascular diseases, such as hypertension and heart failure.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 2-4 µg/ml; FACS: 0.5-1 µg/10^6 cells


Monoclonal Antibody to mTLR9 (Clone: ABM4D70)

Product code: 10-3029
mg

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