|
|
Gene : |
NKX2-2 |
Gene ID : |
4821 |
Uniprot ID : |
O95096 |
Alternative Name : |
NKX2-2, NKX2.2, NKX2B |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
SPM564 |
Isotype : |
Mouse IgG2b, kappa |
Immunogen Information : |
Human NKX2.2 recombinant protein |
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);