Monoclonal Antibody to p21WAF1 (Tumor Suppressor Protein)(Clone : SPM306)

Product code: 36-1004

Clonality : Monoclonal
Application : FACS, IF, WB, IHC
Reactivity : Human

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2000 throughout India Order now and get it on next 3-4 weeks

Size
Price
100 µg
15,000.00 


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Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : CDKN1A
Gene ID : 1026
Uniprot ID : P38936
Alternative Name : CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Format : Purified
Amount : 100 µg
Clone name : SPM306
Isotype : Mouse IgG2a
Immunogen Information : Human recombinant p21 protein
This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Flow Cytometry (0.5-1µg/million cells in 0.1ml); Immunofluorescence (1-2µg/ml); Western Blot (1-2µg/ml); Immunohistologyfollowed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.


Monoclonal Antibody to p21WAF1 (Tumor Suppressor Protein)(Clone : SPM306)

Product code: 36-1004
mg

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