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Gene : |
PAPPA |
Gene ID : |
5069 |
Uniprot ID : |
Q13219 |
Alternative Name : |
Insulin-like growth factor-dependent IGF-binding protein 4 protease, IGF-dependent IGFBP-4 proteas,
Pregnancy-associated plasma protein A |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ABM4C62 |
Isotype : |
Mouse IgG2b Kappa |
Immunogen Information : |
A partial length recombinant PAPP-A protein (amino acids 332-561) was used as the immunogen for this antibody. |
PAPP-A (pregnancy-associated plasma protein A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. It has prognostic impact in pregnancy and acute coronary syndrome. PAPP-A regulate the activity of insulin-like growth factor (IGF) signal pathway through proteolytic degradation of IGF binding proteins (IGFBPs) thereby increasing the local concentration of free IGFs available to receptors. PAPP-A levels is associated with abnormal glucose metabolism and increased risk of atherosclerosis in AGHD (Adult Growth Hormone Deficiency) patients.
Immunohistochemical analysis: 5-10 µg/ml