Monoclonal Antibody to PD-L1 (Clone: ABM4E54)

Product code: 10-7562

Clonality : Monoclonal
Application : IHC, FACS, WB
Reactivity : Human

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2000 throughout India Order now and get it on next 3-4 working days (Major Cities)

Gene : CD274
Gene ID : 29126
Uniprot ID : Q9NZQ7
Alternative Name : CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Format : Purified
Amount : 100 µg
Clone name : ABM4E54
Isotype : Mouse IgG2a Kappa
Immunogen Information : A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody.

PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 2-4 µg/ml; Immunohistochemical analysis-5-10 µg/ml; FACS: 1-2 µg/ml


Monoclonal Antibody to PD-L1 (Clone: ABM4E54)

Product code: 10-7562
mg

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