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|
Gene : |
PODXL |
Gene ID : |
5420 |
Uniprot ID : |
O00592 |
Alternative Name : |
PODXL, PCLP, PCLP1 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
4F10 |
Isotype : |
Mouse IgM, kappa |
Immunogen Information : |
A recombinant protein fragment containing the intracellular, transmembrane, and part of the extracellular domain of human podocalyxin |
Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);