Monoclonal Antibody to Thyroglobulin (Thyroidal Cell Marker)(Clone : SPM517)

Product code: 36-1721

Clonality : Monoclonal
Application : FACS, IHC,
Reactivity : Human, Mouse, Rat

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2000 throughout India Order now and get it on next 3-4 weeks

Size
Price
100 µg


Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : TG
Gene ID : 7038
Uniprot ID : P01266
Alternative Name : TG
Format : Purified
Amount : 100 µg
Clone name : SPM517
Isotype : Mouse IgG1, kappa
Immunogen Information : Human thyroid follicular cells
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. ?Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. ?The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Flow Cytometry (1-2ug/million cells); Immunohistochemistry (Formalin-fixed) (1-2ug/ml; 30 min at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);


Monoclonal Antibody to Thyroglobulin (Thyroidal Cell Marker)(Clone : SPM517)

Product code: 36-1721
mg

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