Monoclonal Antibody to TLR4 (Clone: ABM19C4)

Product code: 10-3010-F

Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : FITC

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Shipping Info:

2000 throughout India Order now and get it on next 3-4 working days (Major Cities)

Gene : TLR4
Gene ID : 7099
Uniprot ID : O00206
Alternative Name : TLR4
Format : Purified
Amount : 100 µg
Clone name : ABM19C4
Isotype : Mouse IgG2b Kappa
Immunogen Information : A partial length recombinant TLR4 protein (amino acids 45-320) was used as the immunogen for this antibody.

TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram?negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.

Purification : Protein G Chromatography
Content : 0.2 mg/ml in Tris buffer and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months.

FACS analysis: 2-4 µg/10^6


Monoclonal Antibody to TLR4 (Clone: ABM19C4)

Product code: 10-3010-F
mg

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