Monoclonal Antibody to ZAP70 (Chronic Lymphocytic Leukemia Marker)(ZAP70/528 + 2F3.2)

Product code: 36-1815

Clonality : Monoclonal
Application : IHC
Reactivity : Human

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2000 throughout India Order now and get it on next 3-4 weeks

Size
Price
100 µg


Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : ZAP70
Gene ID : 7535
Uniprot ID : P43403
Alternative Name : ZAP70, SRK
Format : Purified
Amount : 100 µg
Clone name : ZAP70/528 + 2F3.2
Isotype : Mouse IgG2a, kappa + Mouse IgG2a, kappa
Immunogen Information : Recombinant full-length human ZAP70 protein (ZAP70/528); Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70 (2F3.2)
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.?Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.?Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);


Monoclonal Antibody to ZAP70 (Chronic Lymphocytic Leukemia Marker)(ZAP70/528 + 2F3.2)

Product code: 36-1815
mg

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