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Gene : |
ZAP70 |
Gene ID : |
7535 |
Uniprot ID : |
P43403 |
Alternative Name : |
ZAP70, SRK |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ZAP70/528 + 2F3.2 |
Isotype : |
Mouse IgG2a, kappa + Mouse IgG2a, kappa |
Immunogen Information : |
Recombinant full-length human ZAP70 protein (ZAP70/528); Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70 (2F3.2) |
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.?Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.?Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);