|
|
| Gene : |
DDB1 |
| Gene ID : |
1642 |
| Uniprot ID : |
Q16531 |
| Format : |
Purified |
| Amount : |
0.5 mg |
| Clone name : |
PPT10E11VN |
| Isotype : |
mouse IgG2a |
| Immunogen Information : |
r.HBcAg Core ayw Antigen |
Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.
