|
|
Gene : |
CTSC |
Gene ID : |
1075 |
Uniprot ID : |
P53634 |
Alternative Name : |
Cathepsin H, CTSH, CPSB, ACC-4, ACC-5, MGC1519, minichain, DKFZp686B24257. |
Format : |
Purified |
Amount : |
20 µg |
Clone name : |
P3G8AT. |
Isotype : |
Mouse IgG2a heavy chain and ? light chain. |
Immunogen Information : |
Anti-human Cathepsin H mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Cathepsin H amino acids 23-335 purified from E. coli. |
Cathepsin H is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. Cathepsin H is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin H, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of the Cathepsin H gene has been associated with malignant progression of prostate tumors.
Cathepsin H antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.