Mouse Anti Human IL17E(Clone:YR-hIL17E.)

Product code: 32-5773

Clonality : Monoclonal
Application : ELISA, IP, IHC

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Size
Price
1 mg


Shipping Info:

2000 throughout India Order now and get it on next 3-4 Weeks (Major Cities)

Gene : IL25
Gene ID : 64806
Uniprot ID : Q9H293
Alternative Name : IL-25, IL-17E, IL17E, IL25, Interleukin-25.
Format : Purified
Amount : 1 mg
Clone name : YR-hIL17E.
Isotype : mouse IgG2a.
Immunogen Information : r.Human IL-17E
IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn’t induce allergic inflammation in vivo.
Purification : Protein A.
Content : 1mg/ml in PBS (after reconstitution).
Storage condition : In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

Direct ELISA, Immuneprecipitation, immunohistochemistry.


Mouse Anti Human IL17E(Clone:YR-hIL17E.)

Product code: 32-5773
mg

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