Polyclonal Antibody to CD11C

Product code: 11-7547

Clonality : Polyclonal
Application : WB
Reactivity : Human

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Gene : ITGAX
Gene ID : 3687
Uniprot ID : P20702
Alternative Name : ITGAX, CD11C
Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Immunogen Information : A partial length recombinant CD11c protein (amino acids 620-835) was used as the immunogen for this antibody.
CD11c/CD18 (?X?2, p150/95, or complement receptor 4, CR4) is a monocyte/macrophage-enriched integrin that has been reported to bind to a variety of ligands. These include cell surface proteins (LPS, ICAM-1, ICAM-2, ICAM-4 and VCAM-1), extracellular matrix proteins (collagen I), and soluble ligands (iC3b, heparin and fibrinogen). It is expressed in macrophages, monocytes, granulocytes, subsets of T and B cells, and dendritic cells. CD11c functions as a cell surface receptor for numerous soluble factors and proteins. The interaction mediates leukocyte interactions with other cell types and is a signal transducing receptor. It is found primarily on myeloid cells, where its expression is regulated both during differentiation and during monocyte maturation into tissue macrophages.
Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 1-2 µg/ml


Polyclonal Antibody to CD11C

Product code: 11-7547
mg

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