|
|
| Gene : |
BIRC2 |
| Gene ID : |
329 |
| Uniprot ID : |
Q13490 |
| Alternative Name : |
BIRC2, API1, IAP2, MIHB, RNF48 |
| Format : |
Sera |
| Amount : |
50 µl |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A synthetic peptide human cIAP-2 protein (amino acids 532-549 KYIPTEDVSDLPVEEQLR) was used as the immunogen for this antibody |
This antibody recognizes cIAP2; which is a 604 amino acid protein belongs to the family of inhibitor of apoptosis proteins (IAP). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains. In addition to BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. The IAPs, including cIAP2, have widespread tissue protein expression, with expression levels and subcellular localization patterns differing depending on the cell lineage.
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
