Polyclonal Antibody to IDH1 (Isocitrate Dehydrogenase)

Product code: 36-1258

Clonality : Polyclonal
Application : FACS, IF, WB
Reactivity : Human

Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Size
Price
100 µg


Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : IDH1
Gene ID : 3417
Uniprot ID : O75874
Alternative Name : IDH1, PICD
Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Immunogen Information : Recombinant fragment (119 Amino acid residues; aa 296-414) of human IDH1 protein
It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ? ?-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ? ?-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Flow Cytometry (0.5-1µg/million cells); Immunofluorescence (0.5-1µg/ml); Western Blot (0.5-1µg/ml); Optimal dilution for a specific application should be determined.


Polyclonal Antibody to IDH1 (Isocitrate Dehydrogenase)

Product code: 36-1258
mg

Can't read the image? click here to refresh.