Polyclonal Antibody to NALP3/CIAS1/Cryopyrin/PYPAF1

Product code: 11-3024

Clonality : Polyclonal
Application : WB
Reactivity : Human

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Gene : NLRP3
Gene ID : 114548
Uniprot ID : Q96P20
Alternative Name : NLRP3, C1orf7, CIAS1, NALP3, PYPAF1
Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Immunogen Information : A partial recombinant NALP3 protein (amino acids 1-200) was used as the immunogen for this antibody.
NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein-protein interaction, an intermediate nucleotide binding self-oligomerization NACHT domain and a C-terminal domain containing leucine-rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappa? signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 2-4 µg/ml


Polyclonal Antibody to NALP3/CIAS1/Cryopyrin/PYPAF1

Product code: 11-3024
mg

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