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|
| Gene : |
CD274 |
| Gene ID : |
29126 |
| Uniprot ID : |
Q9NZQ7 |
| Alternative Name : |
CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody. |
Programmed death ligand 1/PD-L1 (also called B7-H1 and CD274) is a T cell inhibitory molecule that is expressed on antigen presenting cells (APC) leading to T cell anergy and/or apoptosis upon ligation to its receptor Programmed death-1 (PD-1, CD279) on T cells. PD-L1 is expressed on tumor cells of a subset of breast cancer patients. It could also induce EMT and enhance RCC cell cancer stemness through up-regulation of SREBP-1c. Blocking the immunosuppressive PD-1/PD-L1 pathway has antitumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response.
Western blot analysis: 2-4 µg/ml
