Polyclonal antibody to PTPN13/PTPL1 (FAP1)

Product code: 20-1064

Clonality : Polyclonal
Application : IP, IHC, WB
Reactivity : Human

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2000 throughout India Order now and get it on next 3-4 weeks

Size
Price
50 µl
12,000.00 


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Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : PTPN13
Gene ID : 5783
Uniprot ID : Q12923
Alternative Name : PTPN13, PNP1, PTP1E, PTPL1
Format : Sera
Amount : 50 µl
Isotype : Rabbit IgG
Immunogen Information : A synthetic peptide of human FAP-1 (amino acids 1760-1775 EPTRQENWTPLKNDLE) was used as immunogen for this antibody

This antibody recognizes FAP-1, including FAP-1 isoforms; FAP-1 (also known as Fas-associated phosphatase-1, PTPN13, PTP-BAS, hPTPIE, and PTPL1) is a member of the protein tyrosine phosphatase (PTP) family FAP-1 phosphatase is thought to be important in the Fas signaling pathway. FAP-1 binds to the cytosolic tail of the Fas receptor (Apo1, CD95) and inhibits Fas-induced apoptosis. Increased FAP-1 protein levels in some tumor cell lines and tumor tissues correlates with resistance to Fas-mediated apoptosis. In general, FAP-1 expression has been found to be highest in cell lines and tissues that are relatively resistant to Fas-mediated apoptosis. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line which is consistent with an inhibitory effect of FAP-1 on Fas signal transductions. Additionally, FAP-1 expression correlates with Fas resistant in ovarian cancer cell lines and FAP-1 is commonly expression in ovarian cancers.

Content : 50 µl sera
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200


Polyclonal antibody to PTPN13/PTPL1 (FAP1)

Product code: 20-1064
mg

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