Polyclonal antibody to SMAC/Diablo

Product code: 20-1087

Clonality : Polyclonal
Application : IP, IHC, WB
Reactivity : Human

Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Size
Price
50 µl
12,000.00 


Bulk Order


Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : DIABLO
Gene ID : 56616
Uniprot ID : Q9NR28
Alternative Name : DIABLO, SMAC
Format : Sera
Amount : 50 µl
Isotype : Rabbit IgG
Immunogen Information : A synthetic peptide of SMAC/Diablo (amino acids 56-73 AVPIAQKSEPHSLSSEAL) was used as immunogen for this antibody

Smac/DIABLO (second mitochondrial-derived activator of caspase/direct IAP binding protein with low pI) is encoded by the nucleus and resides as a precursor within the intermembranous space of the mitochondria. During apoptosis, Smac/DIABLO is proteolytically cleaved and released from the mitochondria into the cytosol, where it promotes cell death by interacting with IAPs and inhibiting their anti-apoptotic function. In turn, certain IAPs may degrade Smac/DIABLO and block its cell death function. Smac/DIABLO is expressed in a wide range of normal tissues and some tumor cells lines, and its over-expression in tumor cell lines can trigger both extrinsic and intrinsic apoptosis pathways.

Content : 50 µl sera
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200


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