|
|
| Gene : |
DIABLO |
| Gene ID : |
56616 |
| Uniprot ID : |
Q9NR28 |
| Alternative Name : |
DIABLO, SMAC |
| Format : |
Sera |
| Amount : |
50 µl |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A Full-length recombinant protein of human SMAC was used as immunogen for this antibody |
Smac/DIABLO (second mitochondrial-derived activator of caspase/direct IAP binding protein with low pI) is encoded by the nucleus and resides as a precursor within the intermembranous space of the mitochondria. During apoptosis, Smac/DIABLO is proteolytically cleaved and released from the mitochondria into the cytosol, where it promotes cell death by interacting with IAPs and inhibiting their anti-apoptotic function. In turn, certain IAPs may degrade Smac/DIABLO and block its cell death function. Smac/DIABLO is expressed in a wide range of normal tissues and some tumor cells lines, and its over-expression in tumor cell lines can trigger both extrinsic and intrinsic apoptosis pathways.
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
