Polyclonal antibody to TRAF-2

Product code: 20-1095

Clonality : Polyclonal
Application : WB, IHC, IP
Reactivity : Human, Mouse, Rat

Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

50 µl

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Shipping Info:

2000 throughout India Order now and get it on next 3-4 weeks

Gene : TRAF2
Gene ID : 7186
Uniprot ID : Q12933
Alternative Name : TRAF2, TRAP3
Format : Sera
Amount : 50 µl
Isotype : Rabbit IgG
Immunogen Information : A synthetic peptide of human TRAF-2 (amino acids 87-106 SSSAFPDNAARREVESLPAV) was used as immunogen for this antibody
This antibody recognizes TRAF2, which is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 501 amino acids. It Links TNFRs (TNF Receptors) to the SAPKs (Stress-Activated Protein Kinases) and p38s. TRAF2 can activate ASK1 (Apoptosis Signal-Regulating Kinase-1) in vivo and can interact in vivo with the amino- and carboxyl-terminal noncatalytic domains of the ASK1 polypeptide. Expression of the amino-terminal noncatalytic domain of ASK1 can inhibit TNF and TRAF2 activation of SAPK. TRAF2 is a potential mediator of CD40 signaling. In vitro, TRAF2 and TRAF3 bind to the CD40 Cytoplasmic Tail (CD40CT) with much higher affinity than TRAF5 and TRAF6 (TNF Receptor Associated Factor-6) and that TRAF2 and TRAF3 bind to different residues of the CD40CT. The TRAF2-binding site of the CD40CT is critical for NF-KappaB and SAPK activation, as well as the UP-regulation of the ICAM1 (Intercellular Adhesion Molecule-1).
Content : 50 µl sera
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200

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