|
|
| Gene : |
TRAF4 |
| Gene ID : |
9618 |
| Uniprot ID : |
Q9BUZ4 |
| Alternative Name : |
TRAF4, CART1, MLN62, RNF83 |
| Format : |
Sera |
| Amount : |
50 µl |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A synthetic peptide human TRAF-4 (amino acids 1-17 MPGFDYKFLEKPKRRLL) was used as immunogen for this antibody |
This antibody recognizes TRAF4. Human TRAF4 is a 470 amino acid protein. The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases. TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
