|
|
| Gene : |
IL10 |
| Gene ID : |
3586 |
| Uniprot ID : |
P22301 |
| Alternative Name : |
B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor. |
| Format : |
Purified |
| Amount : |
1 mg |
| Clone name : |
NYRmIL-10. |
| Isotype : |
Rat IgM. |
| Immunogen Information : |
r.Murine IL-10. |
IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Direct ELISA, Western Blot, Immuneprecipitation Immunohistochemistry, Intracellular staining.
