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| Alternative Name : |
Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator
4, C7orf59, Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 4, Chromosome
7 Open Reading Frame 59, Ragulator Complex Protein LAMTOR4, UPF0539 Protein
C7orf59, LAMTOR4. |
| Amount : |
10 µg |
Source : Escherichia Coli.
LAMTOR4 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 122 amino acids (1-99 a.a) and
having a molecular mass of 13.1kDa.
LAMTOR4 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
LAMTOR4 is implicated in amino acid sensing and activation of mTORC1,
which is a signaling complex promoting cell growth in response to growth
factors, energy levels, and amino acids. LAMTOR4 is activated by amino acids via
a mechanism which involves the lysosomal V-ATPase, the Ragulator functions as a
guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator
and Rag GTPases both function as a scaffold recruiting mTORC1 to lysosomes
where it is sequentially activated.
