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Alternative Name : |
Sirtuin 5, NAD-Dependent Lysine Demalonylase And
Desuccinylase Sirtuin-5,Mitochondria, NAD-Dependent Protein Deacylase Sirtuin-5
Mitochondrial, Silent Mating Type Information Regulation 2 (S.Cerevisiae)
Homolog 5, NAD-Dependent Deacetylase Sirtuin-5, |
Amount : |
20 µg |
Source : Escherichia Coli.
SIRT5 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain topological domain containing 300 amino
acids (34-310 a.a) and having a molecular mass of 32.5kDa. SIRT5 is fused to a 23
amino acid His-tag at N-terminus & purified by proprietary chromatographic
techniques.
SIRT5 belongs to the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Sirtuin family members hold a sirtuin core domain and grouped into four classes. The protein encoded by this gene is included in class III of the sirtuin family. Human sirtuins functions were not yet determined; still, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies propose that human sirtuin could operate as intracellular regulatory protein with mono-ADP-ribosyltransferase activity.